TNF and Alzheimer disease: A total of 19 pathways were related to AD disease: TNF signaling pathway, apoptosis, IL-17 signaling pathway, VEGF signaling pathway, Toll-like receptor signaling pathway, HIF-1 signaling pathway, T cell receptor signaling pathway, PI3K–Akt signaling pathway, Ras signaling pathway, inflammatory bowel disease, chemokine signaling pathway, MAPK signaling pathway, NF-κB signaling pathway, Th17 signaling pathway, FoxO signaling pathway, NOD-like receptor signaling pathway, Th1 and Th2 cell differentiation, apoptosis-multi species, and inflammatory mediator regulation of TRP channels.