In carbon tetrachloride (CCl4)-induced hepatic fibrosis rat models, SIRT1 overexpression attenuates the conversion of macrophages to the pro-inflammatory M1 type and inhibits the release of inflammatory cytokines via downregulation of the nuclear factor kappa B (NF-κB)/NLRP3 pathway [28]. The gene discussed is NFKB1; the disease is Hepatic fibrosis.