Several signaling pathways, including estrogen receptor signaling cell growth, cyclin-dependent kinases (CDKs), hypoxia-inducible factor-1 (HIF-1), NF-κBs, PI3K/Akt, and insulin-like growth factor receptor (IGF-1R), have been proposed as potential targets to inhibit cancer proliferation [48]. This evidence concerns the gene AKT1 and cancer.