The latest research has found that 23-demethyl 8,13-deoxygenicin (C45) (Figure 2), a natural inhibitor of cyclophilin A, either as monotherapy or in combination with afatinib, can inhibit the growth of cancer stem cells in non-small-cell lung cancer by disrupting the crosstalk between cyclophilin A/CD147 and EGFR. Here, PPIA is linked to non-small cell lung carcinoma.