Cyclophilin A is identified as a critical component in various biological processes and associated diseases, such as protein folding/trafficking, immune responses, cell signaling, vascular disease pathogenesis, viral infections, rheumatoid arthritis, atherosclerosis, and cancer development [9,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38]. The gene discussed is PPIA; the disease is viral infectious disease.