Han et al. found that cryptotanshinone (3) inhibited the growth of mouse hepatocellular carcinoma (Hepa1-6) cells by inducing apoptosis through blocking the Janus kinase 2 (JAK2)/STAT3 signaling pathway and activated macrophages and polarized mouse bone marrow-derived macrophages towards a classically differentiated macrophage (M1) phenotype in vitro through the toll-like receptor (TLR) 7/myeloid differentiation factor 88 (MyD88)/nuclear factor-κ gene binding (NF-κB) signaling pathway [60]. The gene discussed is JAK2; the disease is hepatocellular carcinoma.