Other studies showed that tanshinone IIA (1) could significantly inhibit the secretion of TNF-α, IL-6, and IL-17 in the peripheral blood of patients with LPS-induced RA by modulating the activity of neutrophils or β-arrestin 2, leading to the attenuation of inflammatory cell infiltration, ankle/knee swelling, synovial hyperplasia, and synovial tissue erosions, etc. [81,82]. This evidence concerns the gene TNF and rheumatoid arthritis.