NFKB1 and rheumatoid arthritis: In addition, cryptotanshinone (3) could downregulate the secretion of inflammatory factors and significantly reduce the production and activity of metalloproteinase (MP)-9 or reduce osteoclastogenesis by inactivating the NF-κB and extracellular regulated protein kinase (ERK) signaling pathways in bone marrow-derived macrophages to alleviate RA [72,73,74,75].