MiR-218-5p and miR-363-3p were found to upregulate p53 expression by binding to the p53 promoter region and binding to the 3′UTR of junction-mediating and regulatory protein (JMY), leading to the downregulation of JMY expression, subsequently promoting mesenchymal-endothelial transition and inhibiting myocardial fibrosis. Here, TP53 is linked to Myocardial fibrosis.