Mechanisms of improving insulin resistance have been presented in several studies, including the regulating activities of crucial enzymes, scavenging radicals, to increase abilities to resist antioxidative stress, increasing insulin sensitivities by upregulating the expression of peroxisome proliferators-activated receptor-γ (PPAR-γ), and stimulating B cells to secrete insulin [191,215,225]. Here, INS is linked to Insulin resistance.