CCND1 and rheumatoid arthritis: In 2015, Miao et al. reported that 50 mg/kg Phellinus polysaccharides taken orally every day by SD mice with rheumatoid arthritis (RA) might improve the condition of RA by inhibiting the Wnt signaling pathway, based on an observation of a decrease in the expression of β-catenin, C-myc, and ccnd1 [148].