NFE2L2 and cartilage disease: Many signalling pathways, such as MAPK (mitogen-activated protein kinases), NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), and NRF2/HO-1 (nuclear factor erythroid 2-related factor 2/haem oxygenase 1), are modulated by genistein in protective mechanisms against bone and cartilage disease [19,21,22].