From the cohort of the Maternal VitD Osteoporosis Study (MAVIDOS), Curtis et al. measured the DNAm at a specific site in the RXRA locus (10 CpG) and found that in the cohort of mothers receiving cholecalciferol, the methylation levels in the RXRA-specific site were significantly lower compared to the placebo group [79]. This evidence concerns the gene RXRA and osteoporosis.