Again, due to the known role of mitochondria in neurodegeneration and Alzheimer’s disease in particular, Mohanad et al. found that VitD was able to improve the oxidative stress and mitochondrial function in a preclinical model of induced AD, through calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2)-mediated phosphorylation of Sirtuin1 (SIRT1) [86]. This evidence concerns the gene CAMKK2 and early-onset autosomal dominant Alzheimer disease.