Obesity is related to chronic low-grade inflammation, with the production of proinflammatory adipokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), leptin, monocyte chemoattractant protein-1 (MCP-1), and resistin [4]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.