CASP3 and chronic myelogenous leukemia, BCR-ABL1 positive: Furthermore, treatment with 40 mM betanin of the human chronic myeloid leukemia cell line-K562 has been demonstrated to induce an intrinsic apoptosis pathway by activating caspase-3, an executioner caspase in apoptotic cascades, and to reduce cell proliferation by 50% [57,58].