In the early stages of cancer development, pre-neoplasic cells experience high levels of ROS, which lead to the production of antioxidants through the overexpression of genes regulated by nuclear factor erythroid 2-related factor 2 (NRF2) and the redirecting of glucose metabolism to produce nicotinamide adenine dinucleotide phosphate (NADPH), an important molecule involved in oxidative stress. Here, NFE2L2 is linked to cancer.