Furthermore, numerous signalling pathways play an essential role in NB, like that of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) (PI3K/AKT/mTOR) pathway, which has emerged as a potential target for therapy since it is involved in tumour malignancy. This evidence concerns the gene AKT1 and neoplasm.