ALK and neuroblastoma: While hereditary tumours have been described as being caused by activating mutations in the kinase tyrosine domain of the oncogene ALK (anaplastic lymphoma kinase), with the gene PHOX2B (paired-like homeobox 2b) also being involved in this process, sporadic NB appears to be associated with single nucleotide polymorphisms (SNPs) in chromosome 6p22, where the gene FLJ22536 is located.