IGF1 and Insulin resistance: Adipose tissue from overweight or obese people produces mediators such as leptin, resistin, TNF-α, IL-1, IL-6, IL-7, and IL-8, important mediators that promote epithelial cell proliferation, block apoptosis of cells, induce oxidative stress, arrest the immune response, induce high levels of insulin-like growth factor-1 (IGF-1), and increase cell proliferation; it also induces insulin resistance or hyperinsulinemia and causes DNA damage [192,193].