In addition, inhibition of GCS expression can promote apoptosis of gastric cancer cells and their cisplatin (DDP)-resistant cancer SGC7901/DDP cell through regulating the expression of Bcl2, Bax, and cysteine-aspartic-acid-specific protease-3 (caspase 3) proteins in the apoptotic pathway, and the expression of GCS also affects the multidrug resistance of gastric cancer cells through the MDR-1 pathway [92]. This evidence concerns the gene CASP3 and gastric cancer.