The absence of an enhancement in glycemic parameters could be due to T2DM patients enrolled in the study of Vanaie et al. [58], which included insulin-dependent individuals, as well as the relatively low dosage of curcumin supplementation in the study developed by Usharani et al. [65] (300 mg/day or 600 mg/day) compared to the dosage of curcumin administered in the study carried out by Hodaei et al. [28] (1500 mg/day). The gene discussed is INS; the disease is type 2 diabetes mellitus.