Currently, there are at least four main kinds of immunotherapy strategies, which include immune checkpoint inhibitors (ICIs) such as Programmed cell Death protein-1 (PD-1) and Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4), chimeric antigen receptor T-cell therapy, tumor vaccines, and peripatetic immunotherapy. This evidence concerns the gene PDCD1 and neoplasm.