Furthermore, we have demonstrated that αMUPA transgenic mice, especially females, exhibited attenuated renal injury/dysfunction in response to AKI, as was evidenced by the lower serum creatinine (SCr) and blood urea nitrogen (BUN), normal renal histologically and attenuated expression of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule (KIM-1) [37]. The gene discussed is HAVCR1; the disease is acute kidney injury.