Mechanically, for example, a lncRNA-CD244 induced by CD244 during tuberculosis infection recruits enhancer of zeste homolog 2 (EZH2), an inducer of H3K27 methylation, to the infg/tnfa promoter, promoting H3K27 trimethylation, suppressing the expression of IFN-γ/TNF-α in CD8+ T cells, and exacerbating the infection [36]. The gene discussed is TNF; the disease is infection.