DKK1 and Alzheimer disease: Tay et al. followed 14 subjects with MCI and 74 with mild-to-moderate AD and measured the scores for the clinical dementia sum of boxes (CDR-SB) at baseline and after one year and assessed the correlations between changes in the CDR-SB and serum levels of Dickkopf-1 (Dkk-1), which is an antagonist of Wnt [75].