NOTCH1 and cancer: The intercluster interaction between HSP90AA1 in cluster 1 and RPS27A, UBA52, UBB and UBC in cluster 2 were also significantly associated with “Signaling by EGFR in cancer” and “Downregulation of ERBB2 signaling.” The intracluster interactions between RPS27A, UBA52, UBB and UBC were also commonly associated with the abovementioned pathways, “Downregulation of ERBB4 signaling,” “Regulation of PTEN localization” and “Signaling by NOTCH1 HD domain mutants in cancer.”