CDF synergizes with 5FU and oxaliplatin to induce apoptosis in chemo-resistant CRC cells by suppressing membrane transporter ABCG2, EGFR, NF-κB, β-catenin, COX-2, c-Myc and Bcl-xL [66]. The gene discussed is NFKB1; the disease is colorectal carcinoma.