EGFR and colorectal carcinoma: Curcumin treatment of CRC cells also downregulates miR-27a, miR-20a, and miR-17-5p to promote transcription factors ZBTB10 and ZBTB4, which inhibit several downstream target genes, including EGFR, c-MET, cyclin D1, and NFκB, resulting in cancer cell growth arrest and apoptosis induction [20,24].