ERBB2 and cancer: Meanwhile, upregulated HSP90AA1 in MS17-treated SW480 cells was also significantly associated with “Signaling by EGFR in cancer” and “Downregulation of ERBB2 signaling.” EGFR (epidermal growth factor receptor), also known as ErbB1/HER1, is a receptor tyrosine kinase that belongs to the ErbB family [113].