In contrast to our hypothesis that CMTM6 as a PD-L1 stabilizing factor could play a prognostic and possibly a predictive role in UTUC, in the treatment decision for ICI therapy, no significantly longer survival was found in the CMTM6 high group regardless of the scoring mode used for the marker. The gene discussed is CD274; the disease is renal pelvis/ureter urothelial carcinoma.