PTPRR and malignant colon neoplasm: Parvimonas micra, which exists in oral mucosa and the gastrointestinal tract, promotes the progression of colon cancer by upregulating miR-218-5p in cells and EVs, inhibiting protein tyrosine phosphatase receptor R (PTPRR), and subsequently activating the Ras/ERK/c-Fos signaling pathway upon cocultivation with human colon cancer cells [90].