On the other hand, cytokines are notoriously described as able to induce cellular senescence as a response program to different stressors [37] and it is nowadays recognized that IFNγ plus TNFα are responsible for the induction of senescence in cancer cells, so that the use of these cytokines is proposed as a general mechanism for arresting cancer progression through the so-called cytokine induced senescence (CIS) [31,38]. Here, TNF is linked to in situ carcinoma.