The following genes at each time point potentially could modulate anti-viral immunity as well as immunopathology: the upregulations of MHC class I-related genes and IFN-related genes 4 and 7 days p.i.; and the downregulations of distinct immune-related genes, including Cd55, 35 days p.i. For example, upregulated MHC class I (H2-D1, H2-K1) and β2 microglobulin (B2m) genes on platelets could result in the modulation of anti-viral CD8+ T cell responses, since platelets can present viral antigens to CD8+ T cells in infections [80,81]. The gene discussed is CD8A; the disease is infection.