To evaluate the efficacy of BH3 mimetics in melanoma cells, two BRAF-mutated melanoma cell lines (A-375, Mel-HO) and two BRAF-WT cell lines (MeWo, SK-Mel-23) were treated with ABT-737, ABT-263, or ABT-199 (ABTs) alone or in combination with S63845. The gene discussed is BRAF; the disease is melanoma.