Although this FN coating may represent a relatively common phenomenon in TEVs produced by different types of cancer cells, our group has reported recently that in some instances TEVs do not display FN on their surface, as it is the case for TEVs produced by the human colorectal carcinoma Colo-320 cells [48], suggesting that in addition to FN, other molecular interactions can be also employed by TEVs to guide their targeting to recipient cells. This evidence concerns the gene FN1 and colorectal carcinoma.