In the mixed cohort of RA and AS patients, anti-CS IgM concentrations significantly increased after both 6 months (481.6 ± 349.6 units; p = 0.045) and 12 months (518.7 ± 335.4 units; p < 0.001) compared to baseline (406.4 ± 250,5 units). The gene discussed is CD40LG; the disease is rheumatoid arthritis.