FLT3 and acute myeloid leukemia: Pathogenic mutations, specifically internal tandem duplication in the juxta-membrane region (exon 14, 15) and point mutations in TKD (exon 20, mainly D835: D835Y, D835V, D835H, D835E, D835N, followed by I836H, I836M, V592A, Y842C, etc.), in the FLT3 gene are linked with a poor prognosis and overexpressed on most AML blasts [9,10].