Leukemias are exemplified by the presence of an activating mutation of the FLT3 transmembrane tyrosine kinase, which is either an internal tandem duplication (ITD) in the JM region, seen in around 20% of AML cases and more frequently within younger adult patients, or the most frequent D835Y point mutation in the activation loop [18]. This evidence concerns the gene FLT3 and acute myeloid leukemia.