FLT3 and acute myeloid leukemia: For instance, a mathematical top–down systems biology approach based on machine learning and pattern recognition models that integrate all the available biological, pharmacological, and medical data has been carried out to simulate the behavior of human physiology in silico, and the models generated were centered around FLT3-mutated AML pathophysiology and the targets of midostaurin, daunorubicin, and cytarabine [53].