HSPA1A and glioblastoma: GBM-derived EVs are enriched in immunostimulatory molecules (MHC I/II), cytoskeleton molecules (actin, myosin, and tubulin), membrane-trafficking proteins (Rab GTPases), and heat shock proteins (Hsps), for instance Hsp60, Hsp70, and Hsp90 [25,26].