TGFBR1 and neoplasm: Regarding small molecules that inhibit kinases, the study conducted using SD-208, a transforming growth factor beta I receptor (TGF-βR1) kinase inhibitor, loaded on macrophage membrane-coated nanoparticles, demonstrated an inhibitory action on the polarization of M2-like macrophages and, therefore, a change in the tumor microenvironment from immunosuppressive (cold tumor) to immunostimulatory (hot tumor) [96].