Another very recent study demonstrated that the association of the CSF-1R inhibitor, PLX3397 (PLX), with the cytokine IL-12, which has the ability to stimulate the host’s immune activity, promoted repolarization of TAM, stimulated the proliferation and activation of T lymphocytes, reduced MDSCs recruitment, and suppressed tumor growth and metastasis [102] (Table 4). This evidence concerns the gene CSF1R and neoplasm.