It might be that the local S. aureus-specific IgE production in CRS occurs in T2 inflammatory states of the nasal tissue preceding or co-occurring with an S. aureus infection, leading to the allergic sensitisation to S. aureus secreted factors, subsequently perpetuating the chronic allergic inflammatory state in individuals with CRS who are colonised by S. aureus. This evidence concerns the gene IGHE and congenital rubella syndrome.