STAT3 and neoplasm: Evs are also implicated in MDSCs increased survival, which has an immunosuppressive and tumor-promoting effect through interacting with the STAT3 pathway, resulting in the upregulation of Chemokine (C-C motif) ligand 5 (CCL5) molecules and (C-C motif) ligand 2 (CCL2) and eventually the further recruitment of tumorigenic immune cells [143].