SMAD4 and familial pancreatic carcinoma: miR-301a-3p and miR-374 also have an oncogenic role in PDAC via inducing migration and increasing the invasiveness of pancreatic cancer cells, with the former targeting SMAD4 expression [46], whereas the latter does so via deregulating Secernin 1 (SRCIN1), leading to its low expression, and to EMT and PDAC progression [47].