AKT1 and neoplasm: The expression levels of miR-21 are closely related to the regulation of tumor-suppressor genes that are implicated in pivotal cell functions and pathways, such as apoptosis and Ras-Raf-MEK-ERK pathways or/and epidermal growth factor receptor (EGFR), or/and PI3K/AKT signaling pathways, respectively [36,37].