Meanwhile, Systemic Lupus Erythematosus (SLE) also constitutes a risk factor for PDAC development based on the meta-analytic data [7], while patients who present another non-modifiable risk factor such as Peutz–Jeghers syndrome, related to STK11 mutation, have a significantly higher risk (132 times higher) of developing it [8]. The gene discussed is STK11; the disease is systemic lupus erythematosus.