SPINK1 and familial pancreatic carcinoma: Focusing on the molecular background of this malignancy, several gene mutations are documented including KRAS, BRCA1, BRCA2, TP53, SMAD4, CTFR, CDKN2A, MLH1, SPINK1, ATM, and PALB2, as well as PRSS1, MSH2, and MSH6. In the cases of familial pancreatic cancer (FPC), the most well-documented genetic alterations include SPINK1, CFTR, and PRSS1 mutations, while CDKN2A and BRCA2 are also highly identified in several other hereditary genetic conditions [9].