TNF and irritable bowel syndrome: The different innate immune cells (neutrophils, macrophages, DCs, and natural killer T- (NKT) cells, etc.), and innate cytokines and molecules (IL-1, TNF, and defensins) found in the intestine, lead to inflammatory response in IBD in response to gut microbial dysbiosis [125].The dysfunction of the intestinal epithelium barrier and release of various inflammatory mediators, neutrophils can prolong intestinal inflammation [5].