GSTM1 and hypertensive disorder: Thus, the observed in vitro binding of Cd2+, Hg2+ and CH3Hg+ to RBC cytosol constituents (i.e., GSH, Hb and other proteins) helps to explain changes in the redox status of the RBCs from fishermen, which, in turn, are implicated in the observed increased prevalence of hypertension and type 2 diabetes (among the 55 fishermen, 34% exhibited hypertension and 11% type 2 diabetes, while in the control group of 25, the corresponding values were 24% and 0%, respectively) [100,101].