Different categories of CF modulators include (i) Potentiators that help the CFTR channel to open [106]; (ii) correctors are pharmacologic chaperones that enhance CFTR trafficking to the plasma membrane by improving CFTR folding [107]; (iii) stabilizers are known to stabilize the CFTR variant at the plasma membrane [108]; (iv) amplifiers increase the amount of CFTR protein [109]; and (v) readthrough agents suppress the premature termination codons and help translate the full-length protein [67]. Here, CFTR is linked to cystic fibrosis.