These include the β2AR-NHERF1-CFTR, MRP4-PDZK1-CFTR, LPA2R-NHERF2-CFTR, and iNOS-NHERF2-CFTR complexes that are expected to form in many CF-relevant epithelial cells [282,283,284,285,286]. This evidence concerns the gene CFTR and cystic fibrosis.