TRG was shown to block the Nrf2-dependent expression of proteasomal genes (s5a/psmd4 and α5/psma5) and reduce proteasome activity in pancreatic carcinoma cell lines (Panc1, Colo357, and MiaPaca2) and H6c7 pancreatic duct cells, leading to apoptosis in these cells [50]. This evidence concerns the gene PSMD4 and exocrine pancreatic carcinoma.