For example, plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) could protect against cerebral ischemia- and spinal cord injury-induced oxidative stress and inflammation by activating the Nrf2–ARE pathway in an STZ-induced AD-like mouse model, which could be ameliorated by TRG [112]. Here, NFE2L2 is linked to Alzheimer disease.