The Ras ERK1/2 signaling pathway also contributes to GC progression by inhibiting the phosphorylation of histone 1.4 at Serine 27 residue through Aurora B. Takahashi et al., in their cohort study involving 122 GC patients, demonstrated that the overexpression of phosphorylated histone H3 is indicative of poor prognosis [62]. Here, MAPK3 is linked to gastric cancer.