The Ras ERK1/2 signaling pathway also contributes to GC progression by inhibiting the phosphorylation of histone 1.4 at Serine 27 residue through Aurora B. Takahashi et al., in their cohort study involving 122 GC patients, demonstrated that the overexpression of phosphorylated histone H3 is indicative of poor prognosis [62]. The gene discussed is AURKB; the disease is gastric cancer.