Studies have shown that promoter methylation of EGFL7 induces a silencing of miR-126; treatment with 5-aza-CdR restores miR-126 expression, with VEGF as a direct target of miR-126, leading to decreased VEGF expression and inhibiting CRC tumor invasion and angiogenesis to some extent [189]. The gene discussed is VEGFA; the disease is colorectal carcinoma.