Concerning pathways selectively regulated by ω3 or ω6 PUFAs in NW subjects, DHA specifically regulated terms associated with immunity and infection (e.g., antigen processing, IL-1 signaling), cancer-related pathways (e.g., TP53 activity, PTEN regulation, TGFβ signaling), as well as extracellular matrix organization and fibrosis (e.g., collagen formation). This evidence concerns the gene PTEN and cancer.