In participants with cognitive impairment, the expression levels of KEGG:M00146’s NDUFA2, NDUFA3, NDUFA4, NDUFA6, NDUFA7, NDUFA10, and NDUFA12 increased, but the expression levels of NDUFA5, NDUFA4L2, and NDUFAB1 marginally decreased (Figure 7). The gene discussed is NDUFAB1; the disease is Cognitive impairment.