A one-unit increase in Apolipoprotein A (OR = 0.97; p-value = 1.91 × 10−14), HDL (OR = 0.22; p-value = 5.76 × 10−7), IGF-1 (OR = 0.99, p-value = 0.0008), and 25(OH)D (OR = 0.89, p-value = 7.74 × 10−7) also showed protective effects and decreased the incidence of cognitive impairment by 3%, 78%, 1%, and 11%, respectively. This evidence concerns the gene IGF1 and Cognitive impairment.