APOE and amyotrophic lateral sclerosis: No difference in disease duration between ALS patients with or without C282Y (p = 0.73). No difference in disease duration between ALS patients with or without H63D (p = 0.25). No difference in site of onset between ALS patients with or without either variant (H63D: 31.1% vs. 28.4% bulbar; p = 0.65, C282Y: 34.0% vs. 28.5% bulbar; p = 0.42). No difference in frequency of either variant between ALS patients with or without ApoE4 (data not reported).