Higher prevalence of bi-carriers of H63D and ApoE4 in female AD patients compared to female controls (OR = 7.13, CI = 2.07–24.6; p = 0.003). Lower prevalence of H63D in male AD patients compared to male controls (OR = 0.198, CI = 0.055–0.715; p = 0.020). The gene discussed is APOE; the disease is Alzheimer disease.