ANGPT4 and neoplasm: Vegf can be targeted and transcriptionally activated by HIF-1 in a hypoxic microenvironment to promote angiogenesis of hepatocellular carcinoma and melanoma tumors [51,52,53]; Eef2k can promote angiogenesis of liver cancer cells through PI3K/Akt and Stat3 [54]; and Angpt4 can promote the proliferation, survival, and invasion of tumor cells, as well as the expansion of vascular tumors [55].