In addition, Socs3 (a negative feedback regulator) plays a role in regulating the JAK/STAT pathway, and it is also a key endogenous feedback inhibitor of pathologic angiogenesis [56], which can inhibit the proliferation and angiogenesis of cancer cells by downregulating the activation of Akt but not Stat3 [57]. The gene discussed is AKT1; the disease is cancer.