CDKN2A and breast carcinoma: For example, in our previous study, which included 55 bone marrow transplant survivors and 43 breast cancer survivors who had received chemotherapy, we found that frail and pre-frail survivors, defined based on the Fried frailty phenotype, were more likely to have a higher p16INK4a expression compared to robust survivors (p-value < 0.01) [72].