EB virus up-regulates SLC7A11 and GPX4 protein levels by affecting the SQSTM1-NRF2-KEAP1 axis to promote the formation of GPX4 and TBK1 complexes and to regulate downstream pathways to reduce the sensitivity of NPC cells to ferroptosis [57]. The gene discussed is TBK1; the disease is nasopharyngeal carcinoma.