The search encompassed keywords and their combinations such as “hypertension”, “chronic kidney disease”, “obesity”, “metabolic syndrome”, “diabetes”, “hyperlipidemia”, “cardiovascular disease”, “developmental programming”, “DOHaD”, “offspring”, “mother”, “nephron”, “pregnancy”, “gestation”, “lactation”, “progeny”, “reprogramming”, “prorenin receptor”, “aldosterone”, “mineralocorticoid receptor”, “angiotensinogen”, “angiotensin-converting enzyme”, “renin”, and “angiotensin”. This evidence concerns the gene ACE and hypertensive disorder.