Although the consequences of this transcriptomic shift in the trisomic microglial population are difficult to anticipate, one possible explanation might be that a higher trisomic microglia reactivity state would promote the release of different proinflammatory cytokines such as IL-6 and TNF-α that might contribute to neuroinflammation that is reported in individuals with DS [51,52]. This evidence concerns the gene IL6 and Dravet syndrome.