In recent years, there have been few studies documenting significant programmed death ligand 1 (PD-L1) expression in undifferentiated pancreatic carcinoma compared to PDAC [18] and the aggressive behavior of UCOGCs expressing PD-L1 compared to PD-L1-negative UCOGCs [19,20]. Here, CD274 is linked to undifferentiated pancreatic carcinoma.