Yang discovered concomitant KRAS and BRCA2 mutations in one UCOGC case using WES [29]; of note, 17% of PDAC have some “BRCAness” genetic signatures associated with homologous recombination deficiency (BRCA2, BRCA1, PALB2, ATM, and RAD51) [30]. The gene discussed is BRCA2; the disease is hyperinsulinemic hypoglycemia, familial, 4.