Yang discovered concomitant KRAS and BRCA2 mutations in one UCOGC case using WES [29]; of note, 17% of PDAC have some “BRCAness” genetic signatures associated with homologous recombination deficiency (BRCA2, BRCA1, PALB2, ATM, and RAD51) [30]. This evidence concerns the gene PALB2 and hyperinsulinemic hypoglycemia, familial, 4.