GJA1 and hypertensive heart disease: The pro-arrhythmic signaling of systemic and tissue inflammation [5,13,103,104,105,106], as well as oxidative stress [5,77,107,108,109], resulting in the downregulation of Cx43 and the deterioration of GJCx43-channel-mediated intermyocyte communication in hypertensive heart diseases [19,20] should be emphasized.