A recent study demonstrated that in diffuse midline glioma, ERK5 regulates the proglycolytic isoenzyme 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) via the activation of transcriptional factor MEF2A [38]. Here, MAPK7 is linked to diffuse midline glioma.