Several subsets of PBMCs were predominantly identified in patients with COVID-19, such as monocytes and T-cells with a high expression of interferon-stimulated genes, including interferon-alpha inducible protein 27 (IFI27), interferon-induced transmembrane protein 3 (IFITM3), or interferon-stimulated gene 15 (ISG15). Here, IFI27 is linked to COVID-19.